Immunization in multiple sclerosis and other childhood immune-mediated disorders of the central nervous system: A review of the literature. (July 2021) - Solmaz, Ismail
Abstract: Childhood is a period where most vaccines are administered in order to build-up immunological memory, and immunization against vaccine-preventable diseases is an essential part of child care and health. The administration of vaccines to children with inflammatory diseases is a frequent point of concern for parents and physicians. Published information on the relation between vaccines and autoinflammatory diseases of the central nervous system (CNS) consists of case and cohort studies and reviews, in great majority on adult patients. Vaccines do not have any established causative or triggering effects on these diseases. Another issue is the immunization schedule of patients with autoinflammatory CNS diseases, specifically the interactions between the disorder, the clinical status, the treatment and the vaccine. In this review, we summarize the existing information between autoinflammatory disorders of the CNS and vaccines in childhood and underline the points to be considered under various treatment regimens. Highlights: No causative association is established between vaccines and demyelinating diseases. Serology for certain viruses should be tested before starting immunosuppressives. Inactivated vaccines can be given while patient is under treatment. Live attenuated vaccines need care and scheduling around immunosuppressive treatment.