Aggregation-induced emission dots assisted non-invasive fluorescence hysterography in near-infrared IIb window. (August 2021)

• Record Type: Journal Article
• Authors: Yu, Xiaoming; Ying, Yanyun; Feng, Zhe; Qi, Ji; Zheng, Junyan; Zhang, Yuhuang; Liu, Juan; Qian, Jun; Tang, Ben Zhong; Zhang, Dan
• Is Part Of: Nano today. Volume 39(2021)
• Publication Date: 2021-08
• Subjects: Hysterography -- Uterine lesions -- NIR-IIb fluorescence imaging -- Aggregation-induced emission dots -- Biosafe and fertility-friendly; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2021.101235
• Languages: English
• ISSNs: 1748-0132

Abstract

Abstract: Uterine diseases seriously threaten the physical and mental health of women. The main principle, when clinicians adopt examinations, is to achieve efficient diagnosis without negative effect on the physical function including fertility. Hysterography in near-infrared (NIR) IIb window (1500–1700 nm) presents perceptibly enhanced signal to background ratio (SBR) and higher penetration capability compared with those beyond 1000 nm and 1300 nm, but lays down high requirements for the biosafety of fluorophores at the same time. Assisted by the biologically excretable aggregation-induced emission (AIE) dots, non-invasive NIR-IIb fluorescence hysterography visualized typical Y-shaped uteruses, real-time uterine peristalsis or the uterine lesions (mimetic disease statuses in clinic) in mouse models. Significantly, after intrauterine perfusion, the reproductive capacity was unimpaired via fertility assessment and histological analysis. This work could inspire some new ideas for non-invasive clinical diagnosis of uterine diseases and effectively promote the clinical translation of AIE dots. Graphical Abstract: ga1 Highlights: Bright aggregation-induced emission dots over 1500 nm benefit deep penetration. Novel dots show no obvious effect on fertility post intravenous or uterine perfusion. Near-infrared-IIb fluorescence imaging enables non-invasive hysterography in vivo. Fluorescence hysterography assists uterine rupture detection and repair surgery. High-definition visualization allows for evaluating uterine obstruction and relief.