Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia. (July 2021)

• Record Type: Journal Article
• Authors: Vanessa Fiorentino, Teresa; Miceli, Sofia; Succurro, Elena; Sciacqua, Angela; Andreozzi, Francesco; Sesti, Giorgio
• Is Part Of: Diabetes research and clinical practice. Volume 177(2021)
• Publication Date: 2021-07
• Subjects: Prediabetes -- Impaired fasting glucose -- Impaired glucose tolerance -- 1h post-load glucose -- Myocardial energetic efficiency -- Cardiovascular disease -- Cardiac energetics; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2021.108883
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aims: Evidence indicate that 1 h post-load glucose levels (1hPG) ≥ 155 mg/dl identify amongst subjects with normal glucose tolerance (NGT) a new category of prediabetes (NGT 1 h-high). A compromised myocardial mechano-energetic efficiency (MEE) is associated with type 2 diabetes and predicts adverse cardiovascular outcomes. Herein, we explored the association between prediabetes conditions such as NGT 1 h-high, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and a decreased MEE. Methods: MEE was assessed by an echocardiography-derived measure in 1467 non-diabetic individuals subdivided according to their glucose tolerance: NGT and 1-hPG < 155 mg/dl (NGT 1 h-low, n = 617), NGT 1 h-high (n = 210), isolated IFG (n = 237), and IGT (n = 403). Results: Subjects with NGT 1 h-high, isolated IFG, and IGT displayed a higher myocardial oxygen consumption, and a decreased MEE in comparison to NGT 1 h-low group. MEE was inversely related to male sex, age, body mass index, total cholesterol, triglycerides, fasting and post-load glucose and insulin, C reactive protein, and positively correlated with insulin sensitivity estimated by the Matsuda index. In a stepwise multivariate linear regression model including several cardio-metabolic risk factors, 1hPG was the major predictor of MEE. Conclusions: Subjects with NGT 1 h-high, isolated IFG, and IGT have a raised myocardial oxygen consumption and a reduced MEE.