Aptamer functionalized nanomaterials for biomedical applications: Recent advances and new horizons. (August 2021)

• Record Type: Journal Article
• Authors: Mahmoudpour, Mansour; Ding, Shichao; Lyu, Zhaoyuan; Ebrahimi, Ghasem; Du, Dan; Ezzati Nazhad Dolatabadi, Jafar; Torbati, Mohammadali; Lin, Yuehe
• Is Part Of: Nano today. Volume 39(2021)
• Publication Date: 2021-08
• Subjects: Nanomaterials -- Aptamers -- Aptasensor -- Biomedical application; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2021.101177
• Languages: English
• ISSNs: 1748-0132

Abstract

Highlights: Aptamer functionalized nanomaterials (AFMs) use in the biomedical field are reviewed. The conjunction strategies for synthesizing novel AFMs are fully introduced. The versatile roles of nanomaterials in advanced AFMs are discussed. AFMs as an efficient nanostructure can be used in drug delivery, bioimaging, & aptasensor. The challenges and perspectives of AFMs research are also addressed. Graphical Abstract: ga1 Abstract: With the advancement of functional nanomaterials and aptamer selection technologies, aptamer functionalized nanomaterials (AFMs) open various methods to design new sensing and imaging technologies. In this perspective, several sensitivity-enhancement methods alongside a wide range of smart nanomaterials have been incorporated to construct new AFMs to use in the biomedical field. This review first introduces the conjunction strategies for synthesizing AFMs. Then, the versatile roles of nanomaterials in advanced AFMs are discussed, including optical indicators, conducting transducer, carriers, catalysts, and other functions. Representative examples of biomedical applications are reviewed with emphasis on drug delivery, bioimaging, and aptasensors. Finally, some challenges and opportunities in this emerging field are presented.