Predicting early recovery of consciousness after cardiac arrest supported by quantitative electroencephalography. (August 2021)

• Record Type: Journal Article
• Authors: Bauerschmidt, Andrew; Eliseyev, Andrey; Doyle, Kevin W.; Velasquez, Angela; Egbebike, Jennifer; Chiu, Wendy; Kumar, Vedika; Alkhachroum, Ayham; Der Nigoghossian, Caroline; Al-Mufti, Fawaz; Rabbani, LeRoy; Brodie, Daniel; Rubinos, Clio; Park, Soojin; Roh, David; Agarwal, Sachin; Claassen, Jan
• Is Part Of: Resuscitation. Volume 165(2021)
• Page Start: 130
• Page End: 137
• Publication Date: 2021-08
• Subjects: Death -- EEG -- Electrocerebral -- Circulatory arrest -- Coma -- Consciousness; Resuscitation -- Periodicals; Resuscitation -- Periodicals; Réanimation -- Périodiques; Electronic journals; 616.025
• DOI: 10.1016/j.resuscitation.2021.06.008
• Languages: English
• ISSNs: 0300-9572

Abstract

Abstract: Objective: To determine the ability of quantitative electroencephalography (QEEG) to improve the accuracy of predicting recovery of consciousness by post-cardiac arrest day 10. Methods: Unconscious survivors of cardiac arrest undergoing daily clinical and EEG assessments through post-cardiac arrest day 10 were studied in a prospective observational cohort study. Power spectral density, local coherence, and permutation entropy were calculated from daily EEG clips following a painful stimulus. Recovery of consciousness was defined as following at least simple commands by day 10. We determined the impact of EEG metrics to predict recovery when analyzed with established predictors of recovery using partial least squares regression models. Explained variance analysis identified which features contributed most to the predictive model. Results: 367 EEG epochs from 98 subjects were analyzed in conjunction with clinical measures. Highest prediction accuracy was achieved when adding QEEG features from post-arrest days 4–6 to established predictors (area under the receiver operating curve improved from 0.81 ± 0.04 to 0.86 ± 0.05). Prediction accuracy decreased from 0.84 ± 0.04 to 0.79 ± 0.04 when adding QEEG features from post-arrest days 1–3. Patients with recovery of command-following by day 10 showed higher coherence across the frequency spectrum and higher centro-occipital delta-frequency spectral power by days 4–6, and globally-higher theta range permutation entropy by days 7–10. Conclusions: Adding quantitative EEG metrics to established predictors of recovery allows modest improvement of prediction accuracy for recovery of consciousness, when obtained within a week of cardiac arrest. Further research is needed to determine the best strategy for integration of QEEG data into prognostic models in this patient population.