Preoperative prediction of high-risk endometrial cancer by expert and non-expert transvaginal ultrasonography, magnetic resonance imaging, and endometrial histology. (August 2021)

• Record Type: Journal Article
• Authors: Dueholm, Margit; Hjorth, Ina Marie; Dahl, Katja; Marinovskij, Edvard; Ørtoft, Gitte
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 263(2021)
• Page Start: 181
• Page End: 191
• Publication Date: 2021-08
• Subjects: AUC area under receiver operating characteristic curve -- ESMO/ESTRO/ESGO European Society for Medical Oncology/European Society for Radiotherapy & Oncology/European Society of Gynaecological Oncology -- Expert-TVS transvaginal ultrasonography by expert -- LND lymph node dissection -- MRI magnetic resonance imaging -- MI myometrial involvement -- Non-expert-TVS transvaginal ultrasonography by obstetrics and gynecology resident at first visit -- ROC receiver operating characteristic -- SLND sentinel lymph node dissection -- TVS transvaginal ultrasonography; Transvaginal ultrasonography -- Magnetic resonance imaging -- Endometrial neoplasm -- Sensitivity and specificity; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2021.05.041
• Languages: English
• ISSNs: 0301-2115

Abstract

Highlights: Diagnostic performance of expert-TVS and MRI were comparable. Non- expert-TVS had lower efficiency than expert-TVS and MRI, but highest sensitivity. Addition of MRI if myometrial invasion was ≥50 % at non expert TVS was very efficient. This simple strategy and preoperative sampling spared MRI in 61 % of patients. Abstract: Objective: To identify women with high-risk endometrial cancers using expert and non-expert transvaginal ultrasonography (TVS) and MRI. Study design: Myometrial involvement was prospectively evaluated in patients with atypical hyperplasia or endometrial cancer on ultrasound by non-experts at first visit (non-expert-TVS: n = 266) and experts (expert-TVS: n = 188) at second visit. MRI ( n = 175) was performed when high-risk cancer was suspected on non-expert-TVS. Preoperatively, high-risk cancer was defined as myometrial involvement ≥50 %, or preoperative unfavorable tumor histology (grade 3 endometrioid, non-endometrioid tumors, or tumor in cervical biopsies) obtained by endometrial sampling or hysteroscopic biopsies. Preoperative evaluations were compared with final histopathology obtained at surgery, high-risk cancer being defined as unfavorable tumor histology or patients with FIGO stage ≥1b. Results: Preoperative unfavorable tumor histology was seen in 64 women and correctly identified 63 of 128 high-risk cancers. Preoperative diagnosis of unfavorable tumor histology or myometrial involvement ≥50 %, i.e. judged high-risk, had an area under the curve (AUC), sensitivity, and specificity of 79.5 %, 93.8 %, 65.2 % on non-expert-TVS; 85.5 %, 84.4 %, 86.5 % on expert-TVS, and 85.4 %, 89.6 %, 81.2 % on MRI. AUC values were not significantly different between MRI and expert-TVS, but lower on non-expert-TVS ( p < 0.02). However, sensitivity was highest on non-expert-TVS, where a low cutpoint for myometrial involvement was used (included potentially deep and difficult evaluations) in contrast to an exact cutpoint of myometrial involvement ≥50 % used on expert-TVS and MRI. The highest AUC, 88.6 %, was seen when MRI was performed in patients with myometrial involvement ≥50 %, determined on non-expert TVS. Sensitivity was reduced to 85.9 %, while specificity increased to 91.3 %. Thus, MRI was needed for risk classification in only 104 (39 %) patients. Conclusion: Diagnostically, expert-TVS and MRI were comparable and superior to non-expert-TVS. However, non-expert-TVS classified all patients with unclear myometrial involvement ≥50 %, and thereby only misdiagnosed 6.2 % of high-risk cases. Non-expert-TVS combined with MRI when myometrial involvement was ≥50 % on non-expert-TVS was a simple and effective method comparable with expert imaging to identify low- and high-risk cancer and select patients for SLND. Addition of MRI to the diagnostic regimen was needed in only 39 % of our patients.