E19a2 BCR–ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases. Issue 10 (4th October 2006)

• Record Type: Journal Article
• Authors: Mondal, B C; Majumdar, S; Dasgupta, U B; Chaudhuri, U; Chakrabarti, P; Bhattacharyya, S
• Is Part Of: Journal of clinical pathology. Volume 59:Issue 10(2006)
• Page Start: 1102
• Page End: 1103
• Publication Date: 2006-10-04
• Subjects: CML, chronic myeloid leukaemia; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.2005.029595
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR–ABL fusion transcript e19a2. This finding suggests that CML carrying μ-BCR breakpoint may exhibit a clinical course similar to typical CML.