Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance. Issue 9 (1st September 2000)

• Record Type: Journal Article
• Authors: Montironi, Rodolfo; Mazzucchelli, Roberta; Algaba, Ferran; Lopez-Beltran, Antonio
• Is Part Of: Journal of clinical pathology. Volume 53:Issue 9(2000)
• Page Start: 655
• Page End: 665
• Publication Date: 2000-09-01
• Subjects: prostate -- prostatic intraepithelial neoplasia -- intraductal dysplasia -- intraductal carcinoma -- atypical adenomatous hyperplasia -- prostatic adenocarcinoma -- chemoprevention; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.53.9.655
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : High grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not greatly raise the concentration of serum prostate specific antigen (PSA) or its derivatives, does not induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation decreases the prevalence and extent of PIN, suggesting that this form of treatment might play a role in chemoprevention. Radiotherapy is also associated with a decreased incidence of PIN.