Spontaneous regression of natural killer cell lymphoma. Issue 7 (26th June 2009)

• Record Type: Journal Article
• Authors: Isobe, Y; Aritaka, N; Sasaki, M; Oshimi, K; Sugimoto, K
• Is Part Of: Journal of clinical pathology. Volume 62:Issue 7(2009)
• Page Start: 647
• Page End: 650
• Publication Date: 2009-06-26
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.2008.062976
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Spontaneous tumour regression is extremely rare in aggressive lymphoma. A case of natural killer (NK) cell lymphoma with cutaneous manifestation showed an indolent clinical course, and the relapsed nodular lesion disappeared spontaneously without any treatment. Although only small number of T cells were present in the primary skin lesion, there was massive CD8-positive cytotoxic T cell infiltration in the relapsed lesion. This is believed to be the first report of an abscopal effect on NK cell lymphoma. Infiltration of cytotoxic T cells strongly suggests immunological attack against the lymphoma cells.