Increased gastric production of interleukin-8 and tumour necrosis factor in patients with Helicobacter pylori infection. Issue 2 (February 1995)

• Record Type: Journal Article
• Authors: Fan, X G; Chua, A; Fan, X J; Keeling, P W
• Is Part Of: Journal of clinical pathology. Volume 48:Issue 2(1995)
• Page Start: 133
• Page End: 136
• Publication Date: 1995-02
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.48.2.133
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : AIMS--To investigate the role of interleukin-8 (IL-8) and tumour necrosis factor (TNF) in patients infected with Helicobacter pylori. METHODS--The study population comprised 52 patients with dyspepsia attending for upper gastrointestinal endoscopy. Of these patients, 35 were infected with H pylori. IL-8 and TNF concentrations in plasma, gastric juice, and gastric biopsy homogenate supernatant fluid were measured by radioimmunoassay and L929 cell bioassay, respectively. RESULTS--The concentrations of IL-8 and TNF in gastric juice and gastric biopsy homogenates were substantially greater in patients infected with H pylori. In H pylori positive patients IL-8 concentrations in gastric juice and gastric biopsy homogenates were higher in those with moderate gastritis than in those with mild gastritis. There was a positive correlation between IL-8 and TNF concentrations in gastric juice and gastric biopsy homogenate supernatant fluid from H pylori positive patients. There were no significant differences between H pylori positive and negative patients with respect to IL-8 and TNF plasma concentrations. CONCLUSION--This study suggests that increased gastric production of IL-8 and TNF may be implicated in the pathogenesis of H pylori associated gastroduodenal disease.