Immunohistological studies of lymphoproliferative lesions in a fatal case of Epstein-Barr virus infection. Issue 12 (December 1986)

• Record Type: Journal Article
• Authors: Morgan-Capner, P; Morris, J A; McIllmurray, M B; Thomas, J A; Crawford, D H; Azim, T
• Is Part Of: Journal of clinical pathology. Volume 39:Issue 12(1986)
• Page Start: 1317
• Page End: 1322
• Publication Date: 1986-12
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.39.12.1317
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A fatal case of infectious mononucleosis occurred in a young adult. Abnormal serological features were noted in his mother, although there was no other family history suggesting an inherited defect of immune response to Epstein-Barr virus (EBV). The cellular infiltrate observed in tissues obtained at necropsy was analysed with a range of specific monoclonal and polyclonal antibodies. Polyclonal plasmacytoid B cell proliferation had occurred in many tissues. These cells were positive for EBV nuclear antigen, but viral particles were not seen on ultrastructural examination, and the virus was not isolated, suggesting a non-permissive infection.