Co-localisation of insulin-like growth factor II and the proliferation marker MIB1 in hepatocellular carcinoma cells. Issue 2 (February 1997)

• Record Type: Journal Article
• Authors: Sohda, T; Oka, Y; Iwata, K; Gunn, J; Kamimura, S; Shijo, H; Okumura, M; Yun, K
• Is Part Of: Journal of clinical pathology. Volume 50:Issue 2(1997)
• Page Start: 135
• Page End: 137
• Publication Date: 1997-02
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.50.2.135
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : AIM: To assess the effect of insulin-like growth factor II (IGF-II) on proliferation of hepatocellular carcinoma (HCC) cells. METHODS: Expression of IGF-II mRNA and protein was detected in 10 archival HCC specimens using in situ hybridisation and immunohistochemistry, respectively. Expression of the Ki-67 antigen, a proliferation marker, was determined immunohistochemically on the same sections. RESULTS: Increased expression of IGF-II mRNA and protein was detected in five of the 10 HCCs in cells located at the periphery of tumour nests. The pattern of localisation of IGF-II was almost identical with that of Ki-67 antigen. CONCLUSIONS: Most of the Ki-67 antigen positive cells co-expressed IGF-II, suggesting that IGF-II may act as an autocrine or paracrine growth factor, and may play an important role in the development of HCC.