C reactive protein rapid assay techniques for monitoring resolution of infection in immunosuppressed patients. Issue 7 (July 1984)

• Record Type: Journal Article
• Authors: Harris, R I; Stone, P C; Hudson, A G; Stuart, J
• Is Part Of: Journal of clinical pathology. Volume 37:Issue 7(1984)
• Page Start: 821
• Page End: 825
• Publication Date: 1984-07
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.37.7.821
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Three rapid assay techniques (latex agglutination, laser nephelometry, and EMIT enzyme immunoassay) have been evaluated for serial monitoring of the serum C reactive protein (CRP) concentration in immunosuppressed patients with fever. Radial immunodiffusion assay was used as a reference method. Latex agglutination reliably distinguished between normal and raised serum CRP concentrations. Enzyme immunoassay also provided a result within minutes, showed particularly close correlation (r = 0.967) with the reference method, and was free from interference by lipaemic or icteric sera. In 27% of 55 episodes of fever studied serially in immunosuppressed patients, the enzyme immunoassay provided clinically useful information by indicating incomplete resolution of infection despite resolution of fever.