Paternal smoking and spontaneous abortion: a population-based retrospective cohort study among non-smoking women aged 20–49 years in rural China. Issue 9 (11th June 2018)

• Record Type: Journal Article
• Authors: Wang, Long; Yang, Ying; Liu, Fangchao; Yang, Aimin; Xu, Qin; Wang, Qiaomei; Shen, Haiping; Zhang, Yiping; Yan, Donghai; Peng, Zuoqi; He, Yuan; Wang, Yuanyuan; Xu, Jihong; Zhao, Jun; Zhang, Hongguang; Zhang, Ya; Dai, Qiaoyun; Ma, Xu
• Is Part Of: Journal of epidemiology and community health. Volume 72:Issue 9(2018)
• Page Start: 783
• Page End: 789
• Publication Date: 2018-06-11
• Subjects: tobacco smoking pollution -- smoking cessation -- paternal smoking -- preconception -- abortion -- spontaneous; Public health -- Periodicals; Epidemiology -- Periodicals; 614.4
• DOI: 10.1136/jech-2017-210311
• Languages: English
• ISSNs: 0143-005X

Abstract

Abstract : Background: To comprehensively evaluate the association of paternal smoking and spontaneous abortion. Methods: We conducted a population-based retrospective cohort study among 5 770 691 non-smoking rural Chinese women, along with their husbands, participating in the National Free Pre-Pregnancy Checkups Project, regarding outcome events that occurred in 2010–2016. The main outcome was spontaneous abortion (SA). Multivariable logistic regression was used to estimate OR and 95% CI, and restricted cubic spline was used to estimate the non-linear relationship. Results: The multivariable-adjusted OR of exposure to paternal smoking for SA was 1.17 (95% CI 1.16 to 1.19), compared with women without exposure to paternal smoking; and corresponding OR of exposure to preconception paternal smoking for SA was 1.11 (95% CI 1.08 to 1.14), compared with women without exposure to preconception paternal smoking. The ORs of preconception paternal smoking also increased with increases in paternal smoking (pnonlinear <0.05, almost linearly shaped) and preconception paternal smoking (pnonlinear >0.05). In addition, periconception paternal smoking cessation was associated with an 18% (15%–22%) lower risk of SA. Conclusion: Paternal smoking was associated with SA. The importance of tobacco control, specifically pertaining to paternal smoking, should be emphasised during preconception and pregnancy counselling.