Haemorrheological effects of prostaglandin E1 infusion in Raynaud's syndrome. Issue 8 (August 1984)

• Record Type: Journal Article
• Authors: Lucas, G S; Simms, M H; Caldwell, N M; Alexander, S J; Stuart, J
• Is Part Of: Journal of clinical pathology. Volume 37:Issue 8(1984)
• Page Start: 870
• Page End: 873
• Publication Date: 1984-08
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.37.8.870
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Eighteen patients with severe Raynaud's syndrome had impaired deformability of erythrocytes, as measured by filtration through 5 micron diameter pores, compared with 19 healthy controls. The patients were given prostaglandin E1 (PGE1) or placebo by intravenous infusion for 72 h to assess the haemorrheological action of PGE1. Contrary to a previous report, PGE1 did not improve erythrocyte filterability. Infusion of PGE1 did, however, evoke an acute phase response with hyperproteinaemia and a leucocytosis and is a potentially important mediator of this stress response in patients with vascular disease.