T-cell nature of leukaemic cells in a case of Sézary's syndrome with 'null-cell' features. Issue 9 (September 1979)

• Record Type: Journal Article
• Authors: Lauriola, L; Musiani, P; Carbone, A; Bartolini, M; Cianciulli, P; Piantelli, M
• Is Part Of: Journal of clinical pathology. Volume 32:Issue 9(1979)
• Page Start: 912
• Page End: 917
• Publication Date: 1979-09
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.32.9.912
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : alpha-naphthyl acetate esterase (ANAE) activity has been investigated in leukaemic cells from peripheral blood in a typical small-cell Sézary syndrome (SS) case in which cerebriform mononuclear cells failed to form E rosettes. The 'dot-like' ANAE positivity found in the majority of these neoplastic cells strongly supports a T-cell origin. In addition, a non-monocytic, non-B-cell nature of Sézary cells is indicated by the lack of Ia-like antigens. Finally, there is evidence of a distinct portion of Sézary cells simultaneously expressing ANAE activity and Fc IgM receptors.