'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung. Issue 11 (30th June 2015)

• Record Type: Journal Article
• Authors: Du, Yina; Guo, Minzhe; Whitsett, Jeffrey A; Xu, Yan
• Is Part Of: Thorax. Volume 70:Issue 11(2015)
• Page Start: 1092
• Page End: 1094
• Publication Date: 2015-06-30
• Subjects: Systemic disease and lungs -- Surfactant protein -- TTF-1 -- Airway Epithelium; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2015-207035
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : We developed LungGENS (Lung Gene Expression iN Single-cell), a web-based bioinformatics resource for querying single-cell gene expression databases by entering a gene symbol or a list of genes or selecting a cell type of their interest. Gene query provides quantitative RNA expression of the gene of interest in each lung cell type. Cell type query returns associated selective gene signatures and genes encoding cell surface markers and transcription factors in interactive heatmap and tables. LungGENS will be broadly applicable in respiratory research, providing a cell-specific RNA expression resource at single-cell resolution. LungGENS is freely available for non-commercial use at https://research.cchmc.org/pbge/lunggens/default.html .