Plasma malondialdehyde and nitric oxide levels in age related macular degeneration. Issue 12 (1st December 2001)

• Record Type: Journal Article
• Authors: Totan, Yüksel; Çekiç, Osman; Borazan, Mehmet; Uz, Efkan; Sög̈üt, Sadık; Akyol, Ömer
• Is Part Of: British journal of ophthalmology. Volume 85:Issue 12(2001)
• Page Start: 1426
• Page End: 1428
• Publication Date: 2001-12-01
• Subjects: malondialdehyde -- nitric oxide -- age related macular degeneration; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.85.12.1426
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : AIMS: To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). METHODS: Plasma nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects. RESULTS: Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively). CONCLUSION: The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.