Parathyroid hormone related protein in hypercalcaemia of Hodgkin's disease. Issue 6 (June 1992)

• Record Type: Journal Article
• Authors: Bolo-Deoku, J; Basu, S; Lakhani, S; Dunne, F; Ratcliffe, W A; Clarke, M; Barron, J L
• Is Part Of: Journal of clinical pathology. Volume 45:Issue 6(1992)
• Page Start: 541
• Page End: 542
• Publication Date: 1992-06
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.45.6.541
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of hypercalcaemia, using an immunohistochemical staining technique for PTHRP on the tumour tissue and an immunoradiometric (IRMA) assay for PTHRP1-86 on the patient's plasma. The plasma PTHRP was less than 0.23 pmol/l in the range found in normocalcaemic controls, and the immunohistochemical staining was not positive for protein. PTHRP did not have a role in the pathogenesis of hypercalcaemia in this patient.