257 THE INFLUENCE OF ADVERSE DONOR FACTORS ON OUTCOME OF PEDIATRIC HEART TRANSPLANTATION - THE MARGINAL DONOR ALLOGRAFT. (1st January 2005)

• Record Type: Journal Article
• Authors: Yao, W.; Saran, M.; Laks, H.; Kobashigawa, J.; Gjertson, D.; Odim, J.
• Is Part Of: Journal of investigative medicine. Volume 53:Number 1(2005)
• Page Start: S123
• Page End: S123
• Publication Date: 2005-01-01
• Subjects: Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.2310/6650.2005.00005.256
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Background: We sought to examine the influence of various marginal donor criteria on pediatric heart transplantation outcome. Methods: We reviewed the medical records of 191 pediatric heart transplants performed in 174 patients from 1984 through 2003 at our institution. Recipients were grouped into four (0, 1, 2, and ≥ 3 marginal factors) based on number of donor marginal criteria. A marginal donor allograft was defined by at least one of the following criteria: hx of cardiac arrest, LVEF≤50%, positive hepatitis B or C serology, dopamine ≥ 10 mcg/kg/min, gender mismatch (female donor), age ≥ 34 yr, allograft ischemia time ≥ 6 hours and donor-recipient weight ratio ≤ 0.8 ≥ 2. Study endpoints were actuarial survival and freedom from rejection. A Cox proportional hazards model was used for statistical analysis. (Table ) Conclusions: Despite a trend in worse outcome the number of marginal donor criteria did not significantly impact the 1 and 3-year freedom from adverse events in pediatric heart transplantation justifying this strategy to increase the potential donor pool.