Prevalence and predictors of intracranial aneurysms in patients with bicuspid aortic valve. Issue 19 (8th June 2017)

• Record Type: Journal Article
• Authors: Egbe, Alexander C; Padang, Ratnasari; Brown, Robert D; Khan, Arooj R; Luis, Sushil A; Huston, John; Akintoye, Emmanuel; Connolly, Heidi M
• Is Part Of: Heart. Volume 103:Issue 19(2017)
• Page Start: 1508
• Page End: 1514
• Publication Date: 2017-06-08
• Subjects: Bicuspid aortic valve -- Coarctation of aorta -- Intracranial aneurysm -- Magnetic resonance angiography; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2016-311076
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To determine the prevalence and outcomes of intracranial aneurysm (IA) in patients with bicuspid aortic valve (BAV). Methods: Retrospective review of patients with BAV who underwent brain MR angiography at the Mayo Clinic from 1994 to 2013. Results: There were 678 patients included in this study—mean age 57±13 years, men 480 (71%), mean follow-up 10±3 years (5913 patient-years). Coarctation of aorta (COA) was present in 154 (23%) patients. There were 59 IAs identified in 52 of 678 patients (7.7%). IA was present in 20/154 patients (12.9%) with COA and 32/524 patients (5.7%) without COA (p<0.001). For the patients without COA, female gender and right–left cusp fusion were risks factors for IA in women after adjustment for all potential variables (HR 1.76, CI 1.31 to 2.68, p=0.03). There was no significant trend in the risk for IA across age tertiles: age ≤40 years versus 41–60 years (HR 1.19, p=0.34), and age 41–60 years versus 61–80 years (HR 1.06, p=0.56). Among the 52 patients with IA, enlargement occurred in three patients (6%), rupture in two patients (4%) and four patients (8%) underwent coil embolisation. For the 626 patients without IA at baseline, no patient developed IA over 7±2 years of imaging follow-up. Conclusions: BAV is associated with a higher prevalence of IA compared to the general population, and this risk is higher in patients with COA, right–left cusp fusion and female gender.