Extending the Salinilactone Family. (10th March 2020)

• Record Type: Journal Article
• Authors: Schlawis, Christian; Harig, Tim; Ehlers, Stephanie; Guillen‐Matus, Dulce G.; Creamer, Kaitlin E.; Jensen, Paul R.; Schulz, Stefan
• Is Part Of: Chembiochem. Volume 21:Number 11(2020)
• Page Start: 1629
• Page End: 1632
• Publication Date: 2020-03-10
• Subjects: A-factor -- biosynthesis -- GC/MS -- microbial volatiles -- toxic compounds; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201900764
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract: Five new members of the salinilactone family, salinilactones D–H, are reported. These bicyclic lactones are produced by Salinispora bacteria and display extended or shortened alkyl side chains relative to the recently reported salinilactones A–C. They were identified by GC/MS, gas chromatographic retention index, and comparison with synthetic samples. We further investigated the occurrence of salinilactones across six newly proposed Salinispora species to gain insight into how compound production varies among taxa. The growth‐inhibiting effect of this compound family on multiple biological systems including non‐ Salinispora actinomycetes was analyzed. Additionally, we found strong evidence for significant cytotoxicity of the title compounds. Abstract : Finding further function : Five new salinilactones have been identified by GC/MS and synthesis, thereby extending the family of salinilactones to eight compounds. Inhibition assays with actinomycetes, tracking of salinilactone production in Salinispora bacteria, and brine shrimp assays provided insight into the occurrence and biological purpose of salinilactones.