Evidence of an immediate hypersensitivity mechanism in systemic lupus erythematosus. Issue 4 (August 1980)

• Record Type: Journal Article
• Authors: Egido, J; Sánchez Crespo, M; Lahoz, C; García, R; López-Trascasa, M; Hernando, L
• Is Part Of: Annals of the rheumatic diseases. Volume 39:Issue 4(1980)
• Page Start: 312
• Page End: 317
• Publication Date: 1980-08
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.39.4.312
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : In 30 patients with systemic lupus erythematosus the number of a circulating basophils was countered in different stages of activity. An inverse correlation was found between the absolute basophils count and anti-DNA antibodies and presumptive circulating immune complexes (as judged by polyethylene glycol precipitation of serum). A positive correlation was found between the absolute basophil count and C3 or C4 levels. IgE on the basophil surface was determined by radioimmunoassay in 7 patients. All of them showed a significantly higher surface IgE number. When the count of circulating basophils was roughly normal, 5 out of the 6 patients showed a positive basophil degranulation test with native DNA. These results suggest the existence of an anti-DNA specific IgE in lupus patients. Depression of the circulating basophil count may be a useful index of lupus activity.