Detection by electron microscope of rod-shaped organisms in synovial membrane from a patient with the arthritis of Whipple's disease. Issue 6 (December 1976)

• Record Type: Journal Article
• Authors: Hawkins, C F; Farr, M; Morris, C J; Hoare, A M; Williamson, N
• Is Part Of: Annals of the rheumatic diseases. Volume 35:Issue 6(1976)
• Page Start: 502
• Page End: 509
• Publication Date: 1976-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.35.6.502
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Rod-shaped organisms identical to those present in the jejunal mucosa have been found in the synovial membrane of a patient with Whipple's disease. These probably caused inflammatory changes which sere reflected in an increase of the cellular content and high enzyme levels (acid phosphatase and 5-nucleotidase) of the synovial fluid. Tetracycline was effective in controlling the bowel lesion but only had a temporary effect upon the arthritis. Erythromycin controlled both the bowel lesion and the arthritis.