Two rare case reports of ingestion of ammonium hydroxide and novel study of gastrointestinal toxicity. Issue 1 (22nd March 2019)

• Record Type: Journal Article
• Authors: Perananthan, Varan; Wijerathna, Thilini; Nagaratnam, Amitesh; Gawarammana, Indika; Dawson, Andrew; Buckley, Nicholas
• Is Part Of: BMJ open gastroenterology. Volume 6:Issue 1(2019)
• Publication Date: 2019-03-22
• Subjects: ammonium hydroxide -- intestinal fatty acid binding protein -- caustic ingestion -- epithelial barrier -- gastrointestinal toxicity; Gastroenterology -- Periodicals; 616.33005
• DOI: 10.1136/bmjgast-2018-000259
• Languages: English
• ISSNs: 2054-4774

Abstract

Abstract : Objective: We report the only two adult cases of NH4 OH ingestion described in literature at the Peradeniya Teaching Hospital in Sri Lanka. Both cases showed clinical evidence of gastrointestinal toxicity and using intestinal fatty acid binding protein (IFABP), a novel biomarker, we attempted to quantify the extent of enterocyte damage. Procalcitonin was also measured as a maker of bacterial sepsis to ascertain whether there was a link between enterocyte damage and infection secondary to bacterial translocation. Cases: A 45-year-old, previously well man was brought in by family with a reduced level of consciousness after ingestion of an unknown quantity of industrial NH4 OH (29% solution) with suicidal intent. Peak IFABP and procalcitonin levels were 1274 pg/mL and 2.0 ng/mL, respectively, 7.7 hours following presumed ingestion. A 23-year-old, previously well woman presented 24 hours after consuming 100 mL of NH4 OH (5.4% solution) used as a cleaning product. She presented with ongoing vomiting and oropharyngeal pain. Her peak IFABP and procalcitonin levels were 865 pg/mL and 5.8 ng/mL, respectively, 27.2 hours following ingestion. Conclusion: We report the only two adult cases of NH4 OH ingestion and describe severe gastrointestinal damage both clinically and biochemically. IFABP, currently only a marker used in research settings, was elevated in both cases but only marginally below that of levels seen in mesenteric ischaemia (levels greater than 1300 pg/mL). The use of a marker for enterocyte damage especially in ingestion of caustic solutions can allow clinicians to monitor progress, predict complications and evaluate the need for further invasive procedures.