Projected clinical benefit of surveillance imaging for early detection and treatment of breast cancer metastases. Issue 1 (12th December 2018)

• Record Type: Journal Article
• Authors: O'Dell, Walter; Takita, Cristiane; Casey‐Sawicki, Katherine; Daily, Karen; Heldermon, Coy D.; Okunieff, Paul
• Is Part Of: Breast journal. Volume 25:Issue 1(2019)
• Page Start: 75
• Page End: 79
• Publication Date: 2018-12-12
• Subjects: body imaging -- breast cancer -- metastases; Breast -- Diseases -- Periodicals; Breast -- Cancer -- Periodicals; 618.19
• DOI: 10.1111/tbj.13153
• Languages: English
• ISSNs: 1075-122X

Abstract

Abstract: This article presents current best knowledge to assess the projected outcomes benefit of adding multi‐modality surveillance imaging to standard follow‐up care for breast cancer patients at high risk (>30%) for developing future metastases. This analysis is motivated by recent preliminary clinical studies that have suggested that augmenting systemic treatment of early‐stage metastases with targeted surgery and/or radiosurgery achieves significant overall survival and disease‐free survival benefit. Our primary aims are to: (a) describe the clinical motivation and scan parameters needed to identify the early onset of metastatic progression in breast cancer patients for effective surgical or radiosurgical treatment; (b) estimate the anticipated survival benefit for high‐risk patients under this recommended protocol; and (c) estimate the radiation risks associated with the repeated body imaging of this protocol.