BTB‐ZF transcription factors, a growing family of regulators of early and late B‐cell development. Issue 6 (18th March 2014)

• Record Type: Journal Article
• Authors: Chevrier, Stéphane; Corcoran, Lynn M
• Is Part Of: Immunology and cell biology. Volume 92:Issue 6(2014)
• Page Start: 481
• Page End: 488
• Publication Date: 2014-03-18
• Subjects: Immunology -- Periodicals; Cytology -- Periodicals; 616.079
• DOI: 10.1038/icb.2014.20
• Languages: English
• ISSNs: 0818-9641

Abstract

Abstract : The differentiation of early B‐cell precursors in the bone marrow into the variety of mature and effector B‐cell subsets of the periphery is a complex process that requires tight regulation at the transcriptional level. Different members of the broad complex, tramtrack, bric‐à‐brac and zinc finger (BTB‐ZF) family of transcription factors have recently been shown to have key roles in many phases of B‐cell development, including early B‐cell development in the bone marrow, peripheral B‐cell maturation and specialization into effector cells during an immune response. This review highlights the critical functions mediated by BTB‐ZF transcription factors within the B‐cell lineage and emphasizes how the deregulation of these transcription factors can lead to B‐cell malignancies.