Three Regioselectively Acylated Flavonoid Aglycone Derivatives in Equimolar Yield at One Blow. Issue 18 (14th May 2018)

• Record Type: Journal Article
• Authors: Kyriakou, Eleni; Kostagianni, Androniki D.; Kellici, Tahsin F.; Giannopoulou, Efstathia; Siatis, Konstantinos E.; Sayyad, Nisar; Kalofonos, Haralabos P.; Mavromoustakos, Thomas; Stamatis, Haralambos; Tzakos, Andreas G.
• Is Part Of: ChemistrySelect. Volume 3:Issue 18(2018)
• Page Start: 5207
• Page End: 5211
• Publication Date: 2018-05-14
• Subjects: Biocatalysis -- Cancer -- Quercetin -- In Silico Studies -- NMR experiments -- Regioselectivity; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201703002
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A simple and time‐effective chemoenzymatic process to obtain three regioselective acylated quercetin analogues in a 1:1:1 ratio in one pot is described. This process overcomes the inherent scaffold intricacy and synthetic complexity of quercetin. Cell proliferation experiments in three breast cancers cell lines pinpoint the high potency of the generated compounds. Abstract : A chemoenzymatic process to generate three regioselectively acylated quercetin derivatives in equimolar yield at one pot is reported. In silico studies suggest a rationale on the enzymatic formation of the three products. Cell proliferation experiments in three breast cancers cell lines unveiled the high potency of the generated compounds.