Drawing with Iron on a Gel Containing a Supramolecular Siderophore. (4th November 2019)

• Record Type: Journal Article
• Authors: Xiao, Songjun; Paukstelis, Paul J.; Ash, Richard D.; Zavalij, Peter Y.; Davis, Jeffery T.
• Is Part Of: Angewandte Chemie. Volume 131:Number 51(2019)
• Page Start: 18605
• Page End: 18608
• Publication Date: 2019-11-04
• Subjects: Eisen -- G-Quadruplexe -- Hydrogele -- Hydroxamsäure -- Selbstorganisation; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201910872
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Guanosine‐5′‐hydroxamic acid (3 ) forms hydrogels when mixed with guanosine (1 ) and KCl. The 5′‐hydroxamic acid (HA) unit is pH‐responsive and also chelates Fe 3+ . When gels are prepared under basic conditions, the 5′‐HA groups are deprotonated and the anionic hydrogel binds cationic thiazole orange (TO), signaled by enhanced fluorescence. The HA nucleoside 3, when immobilized in the G‐quartet gel, acts as a supramolecular siderophore to form red complexes with Fe 3+ . We patterned the hydrogel's surface with FeCl3, by hand and by using a 3D printer. Patterns form instantly, are visible by eye, and can be erased using vitamin C. This hydrogel, combining self‐assembled G‐quartet and siderophore–Fe 3+ motifs, is strong, can be molded into different shapes, and is stable on the bench or under salt water. Abstract : Harte Schale, weiche Materie : pH‐responsive Hydrogele, die als Chelat an Fe 3+ binden können, wurden aus Guanosin‐5′‐hydroxamsäure (HA) hergestellt. Bei hohem pH bindet das Hydrogel Thiazolorange und gibt ein Fluoreszenzsignal ab. Die HA‐Einheiten können auch als supramolekulare Siderophore fungieren und dabei rote Komplexe mit Fe 3+ bilden, was eine Strukturierung der Hydrogel‐Oberfläche mit FeCl3 erlaubt.