Vive la difference: Factors and mechanisms predicting discrepancy between iFR and FFR. Issue 3 (5th September 2019)

• Record Type: Journal Article
• Authors: Kern, Morton J.; Seto, Arnold H.
• Is Part Of: Catheterization and cardiovascular interventions. Volume 94:Issue 3(2019)
• Page Start: 364
• Page End: 366
• Publication Date: 2019-09-05
• Subjects: Heart -- Diseases -- Diagnosis -- Periodicals; Cardiac catheterization -- Periodicals; 616.1207572
• DOI: 10.1002/ccd.28465
• Languages: English
• ISSNs: 1522-1946

Abstract

Key Points: FFR/iFR is discordant in 15–20% of cases, at times causing confusion about revascularization decisions. The CONTRAST substudy identifies lesion location, lesion severity, and bradycardia as major predictors for FFR/iFR discordance, with age a minor predictor. Each of these predictors can be explained physiologically through the mechanisms related to resting and hyperemic pressure loss across different patterns of atherosclerotic stenoses. A logical approach to using both resting and hyperemic pressure ratios is proposed.