A Catalyst‐Free Synthetic Route to Modified Isoflavone via Multi‐Component Reaction. Issue 4 (30th January 2020) - Alizadeh, Abdolali
Abstract: A concise and efficient one‐pot sequential approach for the synthesis of modified isoflavone was developed from a reaction of 3‐formylchromones, malononitrile, various α, α ‐dicyanoolefines, using Et3 N as the base, and EtOH as the solvent, in good yield. The value of this method lies in its short reaction time, convenient purification, no need for a metal catalyst, excellent efficiency, and green solvent. This synthesis involves a Knoevenagel condensation/carbanion formation/ring closure, and finally, an elimination to obtain the respective isoflavonoid derivatives. Abstract : A series of modified isoflavones have been synthesized in excellent yields (60–85 %) via a one‐pot three‐component reaction of 3‐formylchromones, malononitrile, various α, α ‐dicyanoolefines, using Et3 N as the base, and EtOH as the solvent, in good yield. The value of this method lies in its short reaction time, convenient purification, no need for a metal catalyst, good efficiency, and green solvent. This synthesis involves a Knoevenagel condensation/carbanion formation/ring closure, and finally an elimination to obtain the respective isoflavonoid derivatives.