Galactose‐Grafted 2D Nanosheets from the Self‐Assembly of Amphiphilic Janus Dendrimers for the Capture and Agglutination of Escherichia coli. Issue 5 (16th January 2020)

• Record Type: Journal Article
• Authors: Krishnan, Nithiyanandan; Perumal, Devanathan; Atchimnaidu, Siriki; Harikrishnan, Kaloor S.; Golla, Murali; Kumar, Nilima Manoj; Kalathil, Jemshiya; Krishna, Jithu; Vijayan, Dileep K.; Varghese, Reji
• Is Part Of: Chemistry. Volume 26:Issue 5(2020)
• Page Start: 1037
• Page End: 1041
• Publication Date: 2020-01-16
• Subjects: 2D materials -- amphiphiles -- bacterial capture -- fluorescence -- self-assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201905228
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: High aspect ratio, sugar‐decorated 2D nanosheets are ideal candidates for the capture and agglutination of bacteria. Herein, the design and synthesis of two carbohydrate‐based Janus amphiphiles that spontaneously self‐assemble into high aspect ratio 2D sheets are reported. The unique structural features of the sheets include the extremely high aspect ratio and dense display of galactose on the surface. These structural characteristics allow the sheet to act as a supramolecular 2D platform for the capture and agglutination of E. coli through specific multivalent noncovalent interactions, which significantly reduces the mobility of the bacteria and leads to the inhibition of their proliferation. Our results suggest that the design strategy demonstrated here can be applied as a general approach for the crafting of biomolecule‐decorated 2D nanosheets, which can perform as 2D platforms for their interaction with specific targets. Abstract : Amphiphilicity‐driven self‐assembly of galactose‐based Janus amphiphiles into galactose‐decorated 2D nanosheets is reported. These nanosheets can efficiently capture and agglutinate E. coli through specific multivalent interactions between galactose and galactose binding protein in the bacterial pili of E. coli DH5α strain.