Adult neurogenic process in the subventricular zone‐olfactory bulb system is regulated by Tau protein under prolonged stress. (14th May 2021)

• Record Type: Journal Article
• Authors: Dioli, Chrysoula; Patrício, Patrícia; Pinto, Lucilia‐Goreti; Marie, Clemence; Morais, Mónica; Vyas, Sheela; Bessa, João M.; Pinto, Luisa; Sotiropoulos, Ioannis
• Is Part Of: Cell proliferation. Volume 54:Number 7(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-14
• Subjects: chronic stress -- neurogenesis -- olfactory bulb -- oligodendrogenesis -- subventricular zone -- Tau protein; Cell proliferation -- Periodicals; 571.84
• DOI: 10.1111/cpr.13027
• Languages: English
• ISSNs: 0960-7722

Abstract

Abstract: Objectives: The area of the subventricular zone (SVZ) in the adult brain exhibits the highest number of proliferative cells, which, together with the olfactory bulb (OB), maintains constant brain plasticity through the generation, migration and integration of newly born neurons. Despite Tau and its malfunction is increasingly related to deficits of adult hippocampal neurogenesis and brain plasticity under pathological conditions [e.g. in Alzheimer's disease (AD)], it remains unknown whether Tau plays a role in the neurogenic process of the SVZ and OB system under conditions of chronic stress, a well‐known sculptor of brain and risk factor for AD. Materials and methods: Different types of newly born cells in SVZ and OB were analysed in animals that lack Tau gene (Tau‐KO) and their wild‐type littermates (WT) under control or chronic stress conditions. Results: We demonstrate that chronic stress reduced the number of proliferating cells and neuroblasts in the SVZ leading to decreased number of newborn neurons in the OB of adult WT, but not Tau‐KO, mice. Interestingly, while stress‐evoked changes were not detected in OB granular cell layer, Tau‐KO exhibited increased number of mature neurons in this layer indicating altered neuronal migration due to Tau loss. Conclusions: Our findings suggest the critical involvement of Tau in the neurogenesis suppression of SVZ and OB neurogenic niche under stressful conditions highlighting the role of Tau protein as an essential regulator of stress‐driven plasticity deficits. Abstract : Despite Tau and its malfunction is increasingly related to deficits of adult brain plasticity under pathological conditions [ e.g. Alzheimer's disease (AD)], it remains unknown whether Tau plays a role in neurogenic process of the subventricular zone‐olfactory bulb system under conditions of chronic stress, a well‐known sculptor of brain and a risk factor for AD. We hereby demonstrate for the first time that loss of Tau blocks the stress‐evoked suppression of proliferating cells and neuroblasts, but not oligodendrocyte progenitors, in the SVZ leading to reduced newborn neurons in olfactory bulb of adult brain.