Rhodium(iii)-catalyzed oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols. Issue 5 (14th January 2021)

• Record Type: Journal Article
• Authors: Liu, Jidan; Jiang, Jinyuan; Yang, Zhenke; Zeng, Qiaohai; Zheng, Jieying; Zhang, Siying; Zheng, Liyao; Zhang, Shang-Shi; Liu, Zhao-Qing
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 5(2020)
• Page Start: 993
• Page End: 997
• Publication Date: 2021-01-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02323j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient Rh(iii )-catalyzed C–H oxidative alkylation of N -aryl-7-azaindoles with cyclopropanols by merging tandem C–H and C–C cleavage was developed. Abstract : An efficient Rh(iii )-catalyzed C–H oxidative alkylation of N -aryl-7-azaindoles with cyclopropanols by merging tandem C–H and C–C cleavage was developed. This transformation features mild reaction conditions, high regioselectivity, and excellent functional group compatibility. The resulting β-aryl ketone derivatives can be readily transformed into 7-azaindole-containing π-extended polycyclic heteroarenes.