Reversal of desferrioxamine induced auditory neurotoxicity during treatment with Ca-DTPA. Issue 1 (January 1989)

• Record Type: Journal Article
• Authors: Wonke, B; Hoffbrand, A V; Aldouri, M; Wickens, D; Flynn, D; Stearns, M; Warner, P
• Is Part Of: Archives of disease in childhood. Volume 64:Issue 1(1989)
• Page Start: 77
• Page End: 82
• Publication Date: 1989-01
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.64.1.77
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Auditory neurotoxicity occurred in 13 (26%) of 50 evaluable patients receiving long term desferrioxamine chelation. In five of these patients, all of whom were receiving high doses of desferrioxamine, the toxicity caused deafness. These five patients were treated with subcutaneous calcium diethylene triamine pentacetic acid (Ca-DTPA) with zinc supplements instead of desferrioxamine, and their hearing improved during periods of seven to 19 months. Their serum ion concentrations remained unchanged. We suggest that all patients receiving long term desferrioxamine should have audiometric assessments at 6-12 monthly intervals. Ca-DTPA with oral zinc supplements should be considered as alternative to desferrioxamine as an iron chelating treatment in patients with auditory neurotoxicity.