Leukemoid reaction: a rare paraneoplastic event in a case of advanced penile cancer and its management. Issue 8 (12th August 2019)

• Record Type: Journal Article
• Authors: Mishra, Amit Kumar; Mehra, Ketan; Manikandan, Ramanitharan; Dorairajan, Lalgudi Narayanan
• Is Part Of: BMJ case reports. Volume 12:Issue 8(2019)
• Publication Date: 2019-08-12
• Subjects: urological cancer -- urological surgery; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2019-230826
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Leukemoid reaction is a paraneoplastic phenomenon associated predominantly with solid tumours. Malignancies presenting with leukemoid reaction have a grave prognosis. It is defined as persistent neutrophil count greater than 50×103 cells/µL. We report a case of leukemoid reaction in a patient with metastatic penile cancer. A 60-year-old man with partial penectomy status for squamous cell carcinoma of penis on neoadjuvant chemotherapy, presented with left fungating inguinal lymphadenopathy and total leucocyte count 96×103 cells/µL and hypercalcaemia. Leucocytealkaline phosphatase (LAP) score was excessively elevated. The patient underwent left ilioinguinal block dissection along with vastus lateralis flap for defect reconstruction. Postoperatively, the neutrophil counts and serum calcium level normalised. The patient improved clinically and was discharged.