Outcome of invasive pneumococcal disease: a UK based study. Issue 3 (1st September 2000)

• Record Type: Journal Article
• Authors: Shackley, F; Knox, K; Morris, J Bowen; Crook, D; Griffiths, D; Mayon-White, R; George, R; Willocks, L; Moxon, ER
• Is Part Of: Archives of disease in childhood. Volume 83:Issue 3(2000)
• Page Start: 231
• Page End: 233
• Publication Date: 2000-09-01
• Subjects: Streptococcus pneumoniae -- morbidity -- mortality -- outcome; Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.83.3.231
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : METHODS: The records of 106 children aged less than 5 years with invasive disease caused by Streptococcus pneumoniae were reviewed. RESULTS: The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials. CONCLUSIONS: These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.