The genetic control of phenformin 4-hydroxylation. Issue 5 (October 1985)

• Record Type: Journal Article
• Authors: Shah, R R; Evans, D A; Oates, N S; Idle, J R; Smith, R L
• Is Part Of: Journal of medical genetics. Volume 22:Issue 5(1985)
• Page Start: 361
• Page End: 366
• Publication Date: 1985-10
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.22.5.361
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Previously published results of phenformin 4-hydroxylation in 195 unrelated white British volunteers and 87 family members of 27 randomly selected probands have been subjected to genetic analysis. The results clearly show that about 9% of this population has a genetically determined defect in carrying out this oxidation reaction. The character for the defect is inherited in a Mendelian autosomal recessive fashion. The polymorphism shows a substantial degree of dominance.