Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme. Issue 12 (25th September 2006)

• Record Type: Journal Article
• Authors: Zhou, D Q; Hu, Y; Liu, G; Gong, L; Xi, Y; Wen, L
• Is Part Of: British journal of sports medicine. Volume 40:Issue 12(2006)
• Page Start: 988
• Page End: 991
• Publication Date: 2006-09-25
• Subjects: CKMM, muscle-specific creatine kinase -- PCR, polymerase chain reaction; Sports medicine -- Periodicals; 617.1027
• DOI: 10.1136/bjsm.2006.029744
• Languages: English
• ISSNs: 0306-3674

Abstract

Abstract : Objective: To investigate the association between muscle-specific creatine kinase (CKMM) gene polymorphism and the effects of endurance training on running economy. Methods: 102 biologically unrelated male volunteers from northern China performed a 5000-m running programme, with an intensity of 95–105% ventilatory threshold. The protocol was undertaken three times per week and lasted for 18 weeks. Running economy indexes were determined by making the participants run on a treadmill before and after the protocol, and the A/G polymorphism in the 3′ untranslated region of CKMM was detected by polymerase chain reaction-restricted fragment length polymorphism ( Nco I restriction enzyme). Results: Three expected genotypes for CKMM- Nco I (AA, AG and GG) were observed in the participants. After training, all running economy indexes declined markedly. Change in steady-state consumption of oxygen, change in steady-state consumption of oxygen by mean body weight, change in steady-state consumption of oxygen by mean lean body weight and change in ventilatory volume in AG groups were larger than those in AA and GG groups. Conclusions: The findings indicate that the CKMM gene polymorphism may contribute to individual running economy responses to endurance training.