Association of Meniere's disease and retinal vascular calibre: a prospective observational study in China. Issue 10 (2nd October 2018)

• Record Type: Journal Article
• Authors: Wang, Yixu; Diao, Tongxiang; Han, Lin; Tao, Ye; Yu, Lisheng
• Is Part Of: BMJ open. Volume 8:Issue 10(2018)
• Publication Date: 2018-10-02
• Subjects: adult otolaryngology -- neurotology -- medical retina; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2018-022069
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objective: It is believed that Meniere's disease (MD) is associated with vascular disorders, but few studies have reported the relationship between retinal vascular disorders and MD. We evaluated and compared the retinal vascular calibres in patients with MD with healthy subjects matched for age, sex and vascular risk factors using retinal photographs to explore the association between MD and retinal vascular calibre. Study design: A prospective study. Setting: Tertiary referral centre. Participants: Sixty patients with MD and 62 healthy subjects matched for age, sex and vascular risk factors were enrolled in this study. Twenty-four patients with MD had migraines, and 36 patients with MD did not have migraines. Main outcome measure: Retinal vascular calibres were calculated and compared not only between patients with MD and healthy subjects but also between subgroups of patients with MD. Results: Compared with healthy subjects, patients with MD had a slightly larger retinal artery calibre (126.30±10.45vs 119.61±15.86, p=0.006) and a higher retinal artery/vein ratio (0.79±0.09vs 0.75±0.10, p=0.005). Among patients with MD, those with migraines had a larger retinal artery calibre (130.73±11.55vs 123.35±8.61, p=0.006) than those without migraines. Moreover, the presence of migraines and the high frequency of vertigo attacks appeared to increase the retinal artery calibre. Conclusions: Our study suggests that a relationship exists between retinal vascular calibre and MD. Although the pathophysiological relationship between migraine and MD remains unclear, the presence of migraine attacks may aggravate endolymphatic hydrops (EH) and accelerate the outflow of EH in patients with MD. More extensive studies are required to explore the association between retinal vascular calibre and MD.