Ethnic and geographical variation in antiphospholipid (Hughes) syndrome. Issue 12 (26th May 2005)

• Record Type: Journal Article
• Authors: Uthman, I; Khamashta, M
• Is Part Of: Annals of the rheumatic diseases. Volume 64:Issue 12(2005)
• Page Start: 1671
• Page End: 1676
• Publication Date: 2005-05-26
• Subjects: aCL, anticardiolipin antibodies -- aPL, antiphospholipid antibodies -- APS, antiphospholipid syndrome -- aPT, anti-prothrombin antibodies -- β2GPI, β2-glycoprotein I -- LA, lupus anticoagulant -- PT, prothrombin -- SLE, systemic lupus erythematosus; anticardiolipin antibodies -- antiphospholipid antibodies -- antiphospholipid syndrome -- HLA -- lupus anticoagulant; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.2005.038448
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Investigation of the clinical epidemiology of the antiphospholipid syndrome (APS) is in its early stages. During the past 20 years, studies of antiphospholipid antibodies (aPL) and APS have been made in many countries and ethno-geographical groups. aPL appear to occur in all populations studied, with some variations noted in their frequency and in the clinical complications. Environmental and genetic factors contribute to ethnic variation and susceptibility to APS and thus interethnic differences in disease patterns may be due to environmental or genetic factors, or both.