Alclofenac and D-penicillamine. Comparative trial in rheumatoid arthritis. Issue 1 (February 1978)

• Record Type: Journal Article
• Authors: Berry, H; Fernandes, L; Ford-Hutchinson, A W; Evans, S J; Hamilton, E B
• Is Part Of: Annals of the rheumatic diseases. Volume 37:Issue 1(1978)
• Page Start: 93
• Page End: 97
• Publication Date: 1978-02
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.37.1.93
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Forty-six patients with rheumatoid arthritis, 22 receiving D-penicillamine and 2j alclofenac, took part in a 6-month single-bind external observer trial to compare the efficacy and toxicity of these drugs in the treatment of severe rheumatoid arthritis. Both drugs were active and similar in their efficacy at 6 months as judged by clinical and laboratory measurements. Penicillamine was active therapeutically by 3 months, one month before alclofenac. 9 patients, 8 on alclofenac and one on D-penicillamine, had to stop treatment because of lack of effect or toxic effects. Skin rashes within the first week of treatment were a major problem with alclofenac and led to 6 withdrawals.