Dyskeratosis congenita with malignant transformation. (11th January 2011)

• Record Type: Journal Article
• Authors: Ray, Jay Gopal; Swain, Niharika; Ghosh, Ranjan; Richa, ; Pattanayak (Mohanty), Sweta
• Is Part Of: BMJ case reports. Volume 2011
• Publication Date: 2011-01-11
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr.03.2010.2848
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Dyskeratosis congenita (DC) is a rare genodermatosis characterised by a classic triad of dystrophic nails, reticular skin pigmentation and mucous membrane leukoplakic patches, which have a high rate of malignant transformation. The case report presented here deals with a sporadic case of DC without similar clinical presentation in the first-degree and second-degree relatives. Of note in this case, there was rapid malignant transformation in the non-homogeneous nodulo-speckled leukoplakic patch on the dorsum of the tongue.