Lung cancer survival and stage at diagnosis in Australia, Canada, Denmark, Norway, Sweden and the UK: a population-based study, 2004–2007. Issue 6 (11th February 2013)

• Record Type: Journal Article
• Authors: Walters, Sarah; Maringe, Camille; Coleman, Michel P; Peake, Michael D; Butler, John; Young, Nicholas; Bergström, Stefan; Hanna, Louise; Jakobsen, Erik; Kölbeck, Karl; Sundstrøm, Stein; Engholm, Gerda; Gavin, Anna; Gjerstorff, Marianne L; Hatcher, Juanita; Johannesen, Tom Børge; Linklater, Karen M; McGahan, Colleen E; Steward, John; Tracey, Elizabeth; Turner, Donna; Richards, Michael A; Rachet, Bernard
• Other Names: Brostrøm Søren author non-byline.; Bryant Heather author non-byline.; Currow David author non-byline.; Gavin Anna author non-byline.; Gunnarsson Gunilla author non-byline.; Hanson Jane author non-byline.; Harper Todd author non-byline.; Kaasa Stein author non-byline.; Richards Michael A author non-byline.; Sherar Michael author non-byline.; Thomas Bob author non-byline.; Adolfsson Jan author non-byline.; Andersen Ole author non-byline.; Bryant Heather author non-byline.; Coldman Andy author non-byline.; Dhaliwal Dhali author non-byline.; Engholm Gerda author non-byline.; Gavin Anna author non-byline.; Forman David author non-byline.; Gjerstorff Marianne L author non-byline.; Hatcher Juanita author non-byline.; Hosbond Charlotte author non-byline.; Johannesen Tom B author non-byline.; Lambe Mats author non-byline.; Linklater Karen M author non-byline.; Marrett Loraine author non-byline.; McGahan Colleen E author non-byline.; McLaughlin John author non-byline.; Meechan David author non-byline.; Middleton Richard author non-byline.; Milnes Kamini author non-byline.; Nishri Diane author non-byline.; Quin Nicola author non-byline.; Rabenek Linda author non-byline.; Russell Carol author non-byline.; Shin Janey author non-byline.; Steward John author non-byline.; Tracey Elizabeth author non-byline.; Turner Donna author non-byline.; Bergström Stefan author non-byline.; Boyer Michael author non-byline.; Butler John author non-byline.; Evans William author non-byline.; Hanna Louise author non-byline.; Jakobsen Erik author non-byline.; Kölbeck Karl author non-byline.; Lester Jason author non-byline.; McAleese Jonathan author non-byline.; Peake Michael D author non-byline.; Sundstrøm Stein author non-byline.; Young Nicholas author non-byline.; Williamson Ian author non-byline.; Walters Sarah author non-byline.; Maringe Camille author non-byline.; Coleman Michel P author non-byline.; Bernard Rachet author non-byline.;
• Is Part Of: Thorax. Volume 68:Issue 6(2013)
• Page Start: 551
• Page End: 564
• Publication Date: 2013-02-11
• Subjects: Clinical Epidemiology -- Non-Small Cell Lung Cancer -- Small Cell Lung Cancer; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2012-202297
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Background: The authors consider whether differences in stage at diagnosis could explain the variation in lung cancer survival between six developed countries in 2004–2007. Methods: Routinely collected population-based data were obtained on all adults (15–99 years) diagnosed with lung cancer in 2004–2007 and registered in regional and national cancer registries in Australia, Canada, Denmark, Norway, Sweden and the UK. Stage data for 57 352 patients were consolidated from various classification systems. Flexible parametric hazard models on the log cumulative scale were used to estimate net survival at 1 year and the excess hazard up to 18 months after diagnosis. Results: Age-standardised 1-year net survival from non-small cell lung cancer ranged from 30% (UK) to 46% (Sweden). Patients in the UK and Denmark had lower survival than elsewhere, partly because of a more adverse stage distribution. However, there were also wide international differences in stage-specific survival. Net survival from TNM stage I non-small cell lung cancer was 16% lower in the UK than in Sweden, and for TNM stage IV disease survival was 10% lower. Similar patterns were found for small cell lung cancer. Conclusions: There are comparability issues when using population-based data but, even given these constraints, this study shows that, while differences in stage at diagnosis explain some of the international variation in overall lung cancer survival, wide disparities in stage-specific survival exist, suggesting that other factors are also important such as differences in treatment. Stage should be included in international cancer survival studies and the comparability of population-based data should be improved.