Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Cervical Intraepithelial Neoplasia. Issue 4 (1st April 2011)

• Record Type: Journal Article
• Authors: Grimm, Christoph; Watrowski, Rafal; Polterauer, Stephan; Baumühlner, Konstantin; Natter, Camilla; Rahhal, Jasmin; Heinze, Georg; Schuster, Eva; Hefler, Lukas; Reinthaller, Alexander
• Is Part Of: International journal of gynecological cancer. Volume 21:Issue 4(2011)
• Page Start: 597
• Page End: 601
• Publication Date: 2011-04-01
• Subjects: Vascular endothelial growth factor -- Gene -- Polymorphism -- Cervical intraepithelial neoplasia; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0b013e318214557c
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objective: To evaluate the association between 3 vascular endothelial growth factor ( VEGF ) gene polymorphisms and susceptibility of cervical intraepithelial neoplasia (CIN). Materials and Methods: This prospectively collected case-control study investigates three common VEGF gene polymorphisms (ie, VEGF −460 [rs833061], VEGF +405 [rs2010963], and VEGF +936 [rs3025039]) in 203 women with CIN and 209 healthy women by DNA pyrosequencing. Associations between polymorphisms and CIN risk are evaluated with univariate and multivariable models and haplotype analysis. Results: In a multivariable regression model, the variant VEGF +405C allele was associated (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.2-5.1], P = 0.02) with increased susceptibility of CIN independent of number of sexual partners (OR, 2.2; 95% CI, 1.1-4.6; P = 0.03) and smoking (OR, 3.3; 95% CI, 1.6-6.6; P = 0.001). The haplotype VEGF −460C - +405C - +936C was associated with an OR of 5.2 (95% CI, 1.2-52.7) for the susceptibility of CIN. Conclusions: The presence of the variant VEGF +405C allele and the haplotype VEGF −460C - +405C - +936C are independently associated with higher susceptibility of CIN.