Testosterone measurements in early infancy. Issue 6 (21st October 2004)

• Record Type: Journal Article
• Authors: Tomlinson, C; Macintyre, H; Dorrian, C A; Ahmed, S F; Wallace, A M
• Is Part Of: Archives of disease in childhood. Volume 89:Issue 6(2004)
• Page Start: F558
• Page End: F559
• Publication Date: 2004-10-21
• Subjects: intersex -- sex differentiation -- sex steroids -- testosterone -- assay methods; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/adc.2003.034017
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : Circulating testosterone concentrations in infants measured by a direct chemiluminescent immunoassay (Bayer ADVIA Centaur) were compared with those measured by a traditional radioimmunoassay using solvent extraction. The results confirm that neonatal circulating testosterone concentrations are method dependent, and each laboratory should establish method related reference ranges especially if using a direct commercial immunoassay. The results indicate that the Bayer ADVIA Centaur procedure can be used reliably in neonates. Expected values for male and female infants < 10 days old were 2.5–11.1 (n = 36) and 1.7–5.6 (n = 36) nmol/l respectively. For older neonates (10–50 days) the ranges were 0.2–17.2 (n = 42) and 0.1–1.5 (n = 7) nmol/l respectively.