Antibacterial action of the urease inhibitor acetohydroxamic acid on Helicobacter pylori. Issue 4 (April 1993)

• Record Type: Journal Article
• Authors: Phillips, K; Munster, D J; Allardyce, R A; Bagshaw, P F
• Is Part Of: Journal of clinical pathology. Volume 46:Issue 4(1993)
• Page Start: 372
• Page End: 373
• Publication Date: 1993-04
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.46.4.372
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : The urease inhibitor acetohydroxamic acid (AHA) was assessed for its bacteriostatic and bactericidal effects on Helicobacter pylori. For eight isolates of H pylori, the minimum inhibitory concentration (MIC) was either 200 mg/l or 400 mg/l. Interactions between AHA and antimicrobial drugs used to treat H pylori were also determined. For most isolates AHA reduced the MIC for colloidal bismuth subcitrate (CBS), tetracycline, metronidazole, and amoxicillin. In a few isolates, however, AHA increased the minimum bactericidal concentration (MBC) for these antimicrobial treatments. In vitro AHA is active against H pylori and it interacts with other agents directed against H pylori.