Association between CAM 5.2 and anti-CD1a reactivity in lymph nodes and gastrointestinal tract epithelium. Issue 3 (March 1989)

• Record Type: Journal Article
• Authors: Jack, A S; Grigor, I; O'Brien, C J; McMeekin, W; Lewis, F; McNicol, A M
• Is Part Of: Journal of clinical pathology. Volume 42:Issue 3(1989)
• Page Start: 271
• Page End: 274
• Publication Date: 1989-03
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.42.3.271
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Immunocytochemical studies, using the antibodies CAM 5.2 and NA1/34 (CD1a), were performed on normal lymphoid tissue and malignant lymphomas. A population of dendritic cells in the paracortex of lymph nodes and in T cell lymphomas reacted with both antibodies. Colocalisation with antibodies was also found in gastrointestinal epithelium. Immune blotting shows that the likely basis of this reactivity is a 12 kilodalton peptide which is recognised by both antibodies. This is almost certainly the beta t peptide which has been described as the light chain of CD1a.