Strong evidence against platelet-rich plasma injections for chronic lateral epicondylar tendinopathy: a systematic review. Issue 12 (21st February 2014)

• Record Type: Journal Article
• Authors: de Vos, Robert-Jan; Windt, Johann; Weir, Adam
• Is Part Of: British journal of sports medicine. Volume 48:Issue 12(2014)
• Page Start: 952
• Page End: 956
• Publication Date: 2014-02-21
• Subjects: Tendons -- Elbow Injuries -- Intervention Efficacy -- Sporting Injuries -- Orthopaedics; Sports medicine -- Periodicals; 617.1027
• DOI: 10.1136/bjsports-2013-093281
• Languages: English
• ISSNs: 0306-3674

Abstract

Abstract : Background: Chronic lateral epicondylar tendinopathy is frequent in athletes, and platelet-rich plasma (PRP) is being used increasingly in its treatment. Objective: To systematically review the literature on the efficacy of PRP injections for chronic lateral epicondylar tendinopathy. Methods: The databases of PubMed, EMBASE, CINAHL, Medline OvidSP, Scopus, Google Scholar, Web of Science and Cochrane Library were searched in October 2013. Inclusion criteria were a clinical diagnosis of chronic lateral epicondylar tendinopathy, a randomised controlled trial, an intervention with a PRP injection and the outcome measures described in terms of pain and/or function. One author screened the search results and two authors independently assessed the study quality using the Physiotherapy Evidence Database (PEDro) score. A study was considered to be of high quality if its PEDro score was ≥6. A best evidence synthesis was used to identify the level of evidence. Results: 6 studies were included, of which four were considered to be of high quality. Three high-quality studies (75%) and two low-quality studies showed no significant benefit at the final follow-up measurement or predefined primary outcome score when compared with a control group. One high-quality study (25%) showed a beneficial effect of a PRP injection when compared with a corticosteroid injection (corticosteroid injections are harmful in tendinopathy). Based on the best evidence synthesis, there is strong evidence that PRP injections are not efficacious in chronic lateral epicondylar tendinopathy. Conclusions: There is strong evidence that PRP injections are not efficacious in the management of chronic lateral elbow tendinopathy.