Overexpression of p53 protein in Barrett's syndrome with malignant transformation. Issue 4 (April 1993)

• Record Type: Journal Article
• Authors: Fléjou, J F; Potet, F; Muzeau, F; Le Pelletier, F; Fékété, F; Hénin, D
• Is Part Of: Journal of clinical pathology. Volume 46:Issue 4(1993)
• Page Start: 330
• Page End: 333
• Publication Date: 1993-04
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.46.4.330
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : AIMS--To study the overexpression of p53 protein in Barrett's oesophagus with adenocarcinoma, and to correlate this expression with the pathological features of Barrett's syndrome. METHODS--Immunohistochemical staining was performed on frozen sections with a monoclonal antibody directed against wild type and mutated p53 protein (Pab 1801). Eleven cases of Barrett's adenocarcinoma were studied, seven of which had extensive sampling of benign Barrett's mucosa. RESULTS--Eight of 11 adenocarcinomas overexpressed the p53 protein. Both early and advanced tumours were positive. In Barrett's mucosa around the p53 positive tumours, high grade dysplasia was positive; low grade dysplasia and non-dysplastic mucosa were negative. CONCLUSIONS--P53 gene mutation with ensuing p53 protein overexpression is a common feature of Barrett's adenocarcinoma, both at early and advanced stages. This mutation appears as a relatively late event during the neoplastic transformation of Barrett's oesophagus.